Calquence® (acalabrutinib) is a targeted cancer treatment that belongs to a class of drugs called Bruton’s tyrosine kinase (BTK) inhibitors. It is widely prescribed for certain blood cancers, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and mantle cell lymphoma (MCL). By blocking BTK proteins, Calquence helps slow down or stop cancer cells from growing and spreading.
In this patient-friendly guide, you’ll learn what Calquence is, how it works, who may benefit from it, dosage instructions, potential side effects, safety precautions, cost details, and answers to common questions.
Quick Disclaimer
This article is for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting, stopping, or changing any medication.
What Is Calquence?
Calquence is the brand name for acalabrutinib, a prescription oral medication approved by the U.S. FDA and the European Medicines Agency. It is part of a newer generation of BTK inhibitors designed to be more selective, meaning it blocks cancer cell growth with fewer off-target effects compared to earlier drugs in this class.
Approved Indications
- Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL): Common slow-growing blood cancers.
- Mantle Cell Lymphoma (MCL): A rare but aggressive type of non-Hodgkin’s lymphoma.
Available Forms
- Oral capsules: 100 mg strength
- Usually prescribed as one capsule twice daily
How Does Calquence Work?
Calquence works by blocking Bruton’s tyrosine kinase (BTK), a protein that helps B-cells (a type of white blood cell) grow and survive. In cancers like CLL or MCL, B-cells become abnormal and multiply uncontrollably.
- BTK inhibition: Stops signals that tell cancer cells to grow.
- Cell death: Leads to cancer cell death or prevents their spread.
- Targeted action: Designed to minimize effects on other proteins, reducing some side effects compared to older treatments.
In simple terms, Calquence helps restore balance by slowing down cancer cells while allowing healthy cells to recover.
Common Uses of Calquence
Doctors prescribe Calquence mainly for:
- Chronic Lymphocytic Leukemia (CLL): Helps manage both newly diagnosed and relapsed/refractory cases.
- Small Lymphocytic Lymphoma (SLL): Similar to CLL, often treated the same way.
- Mantle Cell Lymphoma (MCL): Typically used after at least one prior therapy.
Calquence is sometimes used alone (monotherapy) or in combination with other drugs such as obinutuzumab.
Dosage and Administration
Always follow your doctor’s exact instructions. Typical directions are:
- Adults: 100 mg capsule taken every 12 hours (morning and evening).
- With or without food: Swallow whole with water; do not open, break, or chew capsules.
- Missed dose: If less than 3 hours late, take it right away; otherwise skip and resume regular schedule.
Step-by-Step Tips
- Take at the same time each day.
- Avoid grapefruit, Seville oranges, or supplements containing them (they affect drug absorption).
- Inform your doctor about all other medications—especially blood thinners, antifungals, or antibiotics.
Side Effects of Calquence
Common Side Effects (mild to moderate)
- Headache
- Fatigue
- Diarrhea
- Muscle and joint pain
- Bruising or bleeding more easily
- Cough or upper respiratory infection
Less Common but Serious Side Effects
- Atrial fibrillation (irregular heartbeat) – monitor for palpitations or dizziness.
- Severe bleeding – rare, but possible in patients on anticoagulants.
- Infections – weakened immune system may increase risk.
- Secondary cancers – long-term therapy may raise the chance of skin cancers.
If you notice rash, chest pain, rapid heartbeat, or unusual bleeding, seek medical help immediately.
Warnings and Precautions
- Bleeding Risk: Use caution if you’re on aspirin, warfarin, or other blood thinners.
- Heart Problems: Tell your doctor if you have heart disease.
- Infections: Frequent monitoring is required.
- Pregnancy & Breastfeeding: Not recommended; may harm unborn or nursing babies.
- Drug Interactions: Avoid strong CYP3A inhibitors (like ketoconazole) or inducers (like rifampin).
Drug and Product Interactions
- Avoid acid-reducing agents: Proton pump inhibitors (omeprazole) may lower drug levels.
- Use caution with antifungals/antibiotics: May increase Calquence levels.
- Herbal supplements: St. John’s wort can decrease effectiveness.
Always give your doctor a complete list of medicines and supplements you take.
Calquence vs Other Treatments
| Feature | Calquence (Acalabrutinib) | Imbruvica (Ibrutinib) | Zanubrutinib |
|---|---|---|---|
| BTK Selectivity | More selective | Less selective | High selectivity |
| Common Uses | CLL, SLL, MCL | CLL, SLL, Waldenström’s | CLL, SLL |
| Side Effects | Generally fewer headaches, less diarrhea | More bleeding, cardiac side effects | Similar to Calquence |
| Cost | High (varies by insurance/region) | High | High |
Calquence is often chosen for patients who need effective BTK inhibition with potentially fewer heart-related side effects.
Cost and Availability
Calquence is a brand-only medication, and no generic acalabrutinib is currently available.
- Average monthly cost (U.S.): $12,000 – $14,000 before insurance.
- Insurance/Medicare: Many plans cover it, but prior authorization may be required.
- Patient assistance: AstraZeneca offers support programs to reduce out-of-pocket costs.
Special Section: Calquence 100 mg Capsules
- Standard capsule size used worldwide.
- Orange-colored capsule with “ACA 100 mg” marking.
- Packaged in blister packs for safety and ease of dosing.
Proper Care While on Calquence
- Protect skin from sunburn (higher risk of skin cancer).
- Keep good dental hygiene—bleeding gums may occur.
- Avoid contact sports or high-risk activities if you bruise easily.
- Store capsules at room temperature, away from heat and moisture.
Frequently Asked Questions (FAQ)
Q1. Is Calquence chemotherapy?
No. It is a targeted therapy, not traditional chemotherapy.
Q2. How long do I need to take Calquence?
Usually long-term, until disease progression or unacceptable side effects occur.
Q3. Can I drink alcohol with Calquence?
Moderate alcohol may be allowed, but consult your doctor due to liver metabolism.
Q4. What foods should I avoid?
Avoid grapefruit, Seville oranges, and related supplements.
Q5. How soon does Calquence start working?
Some patients notice improvements within weeks, but full effects may take months.
Q6. Can Calquence cause hair loss?
Hair thinning is rare; it is less common than with chemotherapy.
Q7. What happens if I stop taking Calquence suddenly?
Cancer may progress—always consult your doctor before stopping.
Q8. Is there a generic version available?
No. Only brand-name Calquence is available.
Q9. Can Calquence be combined with other drugs?
Yes, often with obinutuzumab or other targeted agents.
Q10. Is Calquence safe for elderly patients?
Yes, widely used in older adults with CLL/SLL.
Q11. Can I travel with Calquence?
Yes, but keep capsules in original packaging with prescription label.
Q12. Does Calquence cure cancer?
It does not cure, but it can significantly control and prolong survival in blood cancers.
Final Thoughts
Calquence (acalabrutinib) represents a major step forward in treating CLL, SLL, and MCL. With its targeted action and improved tolerability compared to older BTK inhibitors, it offers patients a reliable long-term therapy option.
Best practices for patients on Calquence:
- Take exactly as prescribed, twice daily.
- Report side effects early to your care team.
- Avoid drug interactions and certain foods.
- Stay consistent with follow-up appointments and blood work.
When used wisely under medical supervision, Calquence can help patients live longer, healthier lives while managing their cancer effectively.
